Asymmetric formal synthesis of schulzeines A and C.

نویسندگان

  • Jaebong Jang
  • Jong-Wha Jung
  • Jaeseung Ahn
  • Jaehoon Sim
  • Dong-Jo Chang
  • Dae-Duk Kim
  • Young-Ger Suh
چکیده

The asymmetric formal synthesis of schulzeines A and C is described. Key features of the synthesis include the efficient and stereoselective construction of the benzoquinolizidine skeleton via the aza-Claisen rearrangement-induced ring expansion of the 1-vinyl-N-glycyl-isoquinoline, which was prepared by the highly enantioselective asymmetric allylation of the 8-benzyloxy-substituted dihydroisoquinoline and by the acid-catalyzed transannulation of the resulting 10-membered lactam.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 10 27  شماره 

صفحات  -

تاریخ انتشار 2012