Asymmetric formal synthesis of schulzeines A and C.
نویسندگان
چکیده
The asymmetric formal synthesis of schulzeines A and C is described. Key features of the synthesis include the efficient and stereoselective construction of the benzoquinolizidine skeleton via the aza-Claisen rearrangement-induced ring expansion of the 1-vinyl-N-glycyl-isoquinoline, which was prepared by the highly enantioselective asymmetric allylation of the 8-benzyloxy-substituted dihydroisoquinoline and by the acid-catalyzed transannulation of the resulting 10-membered lactam.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 27 شماره
صفحات -
تاریخ انتشار 2012